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2 article(s) from Raz, Keren

Understanding the role of active site residues in CotB2 catalysis using a cluster model

Keren Raz,
Ronja Driller,
Thomas Brück,
Bernhard Loll and
Dan T. Major

Beilstein J. Org. Chem. 2020, 16, 50–59, doi:10.3762/bjoc.16.7

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Scheme 1: Mechanism for formation of cyclooctat-9-en-7-ol, published similarly in [42].

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Figure 1: Computed electronic energy profiles (kcal/mol) for the CotB2 cyclase mechanism. The calculations us...

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Figure 2: Intermediates A–I in the active site model. Interactions are marked by dashed orange lines, the int...

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Figure 3: TS structures TS_A_B–TS_G/H_I in the active site model. Interactions are marked by dashed orange li...

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Figure 4: Comparison between gas phase and active site model conformations. A) Intermediate D. B) Intermediat...

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Full Research Paper

Published 08 Jan 2020

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Current understanding and biotechnological application of the bacterial diterpene synthase CotB2

Ronja Driller,
Daniel Garbe,
Norbert Mehlmer,
Monika Fuchs,
Keren Raz,
Dan Thomas Major,
Thomas Brück and
Bernhard Loll

Beilstein J. Org. Chem. 2019, 15, 2355–2368, doi:10.3762/bjoc.15.228

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Figure 1: CotB1 synthesizes geranylgeranyl diphosphate (GGDP) 3 from the substrates dimethylallyl diphosphate...

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Figure 2: The bacterial diterpene synthase CotB2^wt·Mg²⁺₃·F-Dola in the closed, active conformation (PDB-ID 6G...

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Figure 3: Conformational changes of CotB2 upon ligand binding. Superposition of CotB2’s open (teal), pre-cata...

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Figure 4: View into the active site of CotB2^wt·Mg²⁺₃·F-Dola [37] superimposed with CotB2^wt·Mg²⁺_B·GGSDP [36]. (A) The ...

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Figure 5: View into the active site of CotB2^wt·Mg²⁺₃·F-Dola [37]. Identical view as in Figure 4. (A) The bound F-Dola rea...

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Figure 6: The WXXXXXRY motif in protein sequences of diterpene TPS from different bacteria. Highlighted is th...

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Scheme 1: Overview of the altered product portfolio as a result of introduced point mutations in the active s...

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Scheme 2: Catalytic mechanism of CotB2, derived from isotope labeling experiments [34,35], density functional theory...

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Figure 7: (A) The inner surface of the active site is shown in gray. The bound F-Dola reaction intermediate i...

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Scheme 3: Variants of CotB2 open the route to a novel product portfolio with altered cyclic carbon skeletons,...

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Review

Published 02 Oct 2019

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